Autoantibodies in biological agent naive patients with psoriatic arthritis

Autoantibodies in biological agent naive patients with psoriatic arthritis.

BACKGROUND Anti-tumour necrosis factor alpha (anti-TNFalpha) treatment may be associated with the production of autoantibodies, including lupus-specific autoantibodies. OBJECTIVE To investigate the prevalence of autoantibodies in biological agent naive patients with psoriatic arthritis (PsA). METHODS 94 consecutive, prospectively collected, biological agent naive patients with PsA at the Un...

Autoantibodies in patients with psoriatic arthritis on anti-TNFα therapy.

INTRODUCTION Anti-TNFα therapy has been effective in the treatment of patients with refractory psoriatic arthritis (PSA). However, the risk of developing autoantibodies commonly found in rheumatic diseases in PSA patients undergoing this therapy is not clear. OBJECTIVE To evaluate the induction of specific autoantibodies after anti-TNFα therapy in PSA patients. PATIENTS AND METHODS Serum sa...

S100A8/A9 in psoriatic plaques from patients with psoriatic arthritis

OBJECTIVE To evaluate levels of the calcium-binding proteins S100A8 and S100A9 in the skin of patients with psoriatic arthritis. METHODS Skin punch biopsies were obtained from patients with psoriatic arthritis and healthy control subjects. S100A8/A9 were semiquantified via immunohistochemistry and semiquantitative polymerase chain reaction. RESULTS The study included biopsies from nine pati...

Pregnancy Outcomes in Patients with Psoriatic Arthritis.

Cardiovascular Risk in Patients with Psoriatic Arthritis

Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. In addition to skin and joint involvement, there is increasing evidence suggesting that patients with PsA also have an increase in risk of clinical and subclinical cardiovascular diseases, mostly due to accelerating atherosclerosis. Both conventional and nonconventional cardiovascular risk factors contribute to th...